Rash Decisions
Dermsquared Case Reports
Follow real-world dermatology cases from presentation through management, test your clinical reasoning, and explore the rationale behind key treatment decisions.
- Clinical reasoning
- Strengthen your diagnostic and treatment approach
- Real-world cases
- Learn through authentic patient presentations
- Interactive experience
- Engage with cases through quizzes and other interactive elements
Case reports
Where dermatology's toughest calls become teachable moments — real cases, real decisions, from the experts shaping how the specialty practices.
Case ReportSep 3, 20264 min
Utility of Tapinarof Cream 1% in a Case of Severe and Recalcitrant Atopic Dermatitis In a Pediatric Patient
Case author Naiem T. Issa, MD, PhD, presents a case of a 10-year old white male with a 5-year history of atopic dermatitis, allergic rhinitis and exercise-induced asthma.
- Atopic Dermatitis
Case ReportSep 3, 20262 min
Tapinarof 1% Cream Effectively Clears Plaques of the Boney Prominences
Case author Brad Glick, DO, MPH, FAAD, presents the case of a 57-year-old female with worsening plaque psoriasis of the elbow who experienced limited responses to multiple therapies.
- Psoriasis
Case ReportSep 3, 20263 min
Intravenous and subcutaneous spesolimab use in a medically comorbid patient with erythrodermic generalized pustular psoriasis
Case author Angad Arinder Chadha, MD, presents a case of a 72-year-old African American female admitted for management of a generalized pustular psoriasis (GPP) flare.
- Generalized Pustular Psoriasis (GPP)
Case ReportSep 3, 20265 min
Effective Primary Management of an Exacerbation of Atopic Dermatitis Using a Non-Steroidal Topical Therapy
Case authors Lisa C. Lopez-Sanglay, APRN, FNP-BC and James Q. Del Rosso, DO, FAAD, FAOCD present a case of a 15-year-old male with a flare of atopic dermatitis primarily affecting his hands and feet and a severely pruritic rash.
Case ReportSep 3, 20266 min
Lifelong Atopic Dermatitis with Idiopathic Sudomotor Failure: Response to Lebrikizumab After Dupilumab Failure
Dr Jenny Murase presents a case of severe, dupilumab-refractory atopic dermatitis with idiopathic sudomotor failure successfully managed with lebrikizumab.
- Atopic Dermatitis
Case ReportSep 3, 20263 min
When the Hands Don’t Follow the Rest: Managing Chronic Hand Eczema Despite Systemic AD Control
Dr Jenny Murase presents a case of chronic hand eczema persisting despite well-controlled atopic dermatitis on dupilumab, highlighting the role of delgocitinib cream.
- Chronic Hand Eczema
Case ReportSep 3, 20263 min
The Changing Landscape of Topical Therapies: A Fall Clinical Preview
Dermatology has always woven together science and artistry, the molecular with the tangible. As topical innovation surges ahead, balance is being redefined. At this year’s 25th Annual Fall Clinical Dermatology Conference in Las Vegas, that shift will come into sharp focus.
Dermsquared Editorial TeamAuthor
Case ReportSep 3, 20263 min
Jacked on JAKs: The Therapeutic Impact of Dose Escalation in a Case of Refractory Atopic Dermatitis
Case author Graham Litchman, DO, MS, presents a case of a young adult patient with longstanding atopic dermatitis that remained uncontrolled despite multiple prior therapies, prompting consideration of dose escalation with a JAK inhibitor.
- JAK Inhibitors
Case ReportSep 3, 20263 min
Rapid Clearance of Recalcitrant Psoriasis With an IL-17 Inhibitor
Mark Lebwohl, MD, presents a case of a 48-year-old female with a 10-year history of psoriasis who was successfully treated with an IL-17 inhibitor after inadequate response to both phototherapy and a TNF blocker.
Case ReportSep 3, 20262 min
Subcutaneous Spesolimab Use in a Patient with Chronic Recurrent Generalized Pustular Psoriasis (GPP)
Case author Saakshi Khattri, MD, presents a case of a 61-year-old Asian female with a 30-year history of GPP who experienced a flare after months of remission following intravenous spesolimab, prompting a transition to subcutaneous maintenance therapy.
- Generalized Pustular Psoriasis (GPP)
- Biologics
Case ReportSep 3, 20265 min
A Remarkable Result after a Lifetime of Disappointment in the Treatment of Severe, Recalcitrant Psoriasis
Case author Danna Calder, MMSc, PA-C presents a case of a 34-year-old male with severe, recalcitrant psoriasis achieving remarkable improvement after decades of treatment challenges.
- Psoriasis
Case ReportSep 3, 20263 min
Rapid and sustained clearance of severe psoriasis with dual inhibition of IL-17A and IL-17F
Ron Vender, MD, FRCPC, presents the case of a 31-year-old male with an 8-year history of severe psoriasis who was frustrated with the lack of effective treatment options.
- Psoriasis
Case ReportSep 3, 20262 min
A Case of Nonsegmental Vitiligo on the Face and Hands Treated With Combination Topical JAK Inhibitor and Phototherapy
Case authors Mavra Masood, MD, Jennifer Creasor, BSN, and Iltefat Hamzavi, MD, present a case of a 74-year-old female with persistent generalized vitiligo on the face and body.
- Vitiligo
Case ReportSep 3, 20262 min
Successful Management of Basal Cell Carcinoma in a Challenging Location with a Multimodal Approach
Case author Mark Lebwohl, MD, presents a case of a 86-year-old male with a progressively enlarging erythematous nodular mass with overlying telangiectases.
- Skin Cancer
Case ReportSep 3, 20264 min
Accurately Assessing Prognosis for High-Risk Squamous Cell Carcinoma
Case authors Danny Zakria, MD, MBA, Ryan Rivera-Oyola, MD, and Darrell Rigel, MD, MS, present a case of a 58-year-old male with a history of sun exposure and a skin lesion showing signs of malignancy.
- Skin Cancer
Case ReportSep 3, 20265 min
Successful Treatment of Nonsegmental Periorbital Vitiligo
Case author Stephen W. Lewellis, MD, PhD, FAAD, presents a case of a 38-year-old female with loss of pigmentation on her forehead, cheeks, and eyelids who did not respond to prior treatment with a topical corticosteroid or calcineurin inhibitor.
- Vitiligo
Case ReportSep 3, 20263 min
A Life-Saving Treatment in a 60-year Old Patient With Rapid Eruption of Pustules
Case author Boni Elewski, MD and moderator Danny Zakria, MD, MBA, present a case of a 60-year old female who was airlifted in the middle-of-the-night with a rare dermatologic emergency.