Rash Decisions - Dermatology Case Studies
Dermoscopy, Revisited: Seeing With Intention
As the 2026 Winter Clinical Dermatology Conference kicks off in Hawaii, this editorial launches our Continuity Experience with a return to fundamentals, reframing dermoscopy not as pattern memorization, but as disciplined clinical thinking under the scope.
By Dermsquared Editorial Team
When the Hands Don’t Follow the Rest: Managing Chronic Hand Eczema Despite Systemic AD Control
Dr Jenny Murase presents a case of chronic hand eczema persisting despite well-controlled atopic dermatitis on dupilumab, highlighting the role of delgocitinib cream.
By Jenny Murase, MD
Lifelong Atopic Dermatitis with Idiopathic Sudomotor Failure: Response to Lebrikizumab After Dupilumab Failure
Dr Jenny Murase presents a case of severe, dupilumab-refractory atopic dermatitis with idiopathic sudomotor failure successfully managed with lebrikizumab.
By Jenny Murase, MD
The Changing Landscape of Topical Therapies: A Fall Clinical Preview
Dermatology has always woven together science and artistry, the molecular with the tangible. As topical innovation surges ahead, balance is being redefined. At this year’s 25th Annual Fall Clinical Dermatology Conference in Las Vegas, that shift will come into sharp focus.
By Dermsquared Editorial Team
Jacked on JAKs: The Therapeutic Impact of Dose Escalation in a Case of Refractory Atopic Dermatitis
Case author Graham Litchman, DO, MS, presents a case of a young adult patient with longstanding atopic dermatitis that remained uncontrolled despite multiple prior therapies, prompting consideration of dose escalation with a JAK inhibitor.
By Graham Litchman, DO, MS
Intravenous and subcutaneous spesolimab use in a medically comorbid patient with erythrodermic generalized pustular psoriasis
Case author Angad Arinder Chadha, MD, presents a case of a 72-year-old African American female admitted for management of a generalized pustular psoriasis (GPP) flare.
By Angad Arinder Chadha, MD
Utility of Tapinarof Cream 1% in a Case of Severe and Recalcitrant Atopic Dermatitis In a Pediatric Patient
Case author Naiem T. Issa, MD, PhD, presents a case of a 10-year old white male with a 5-year history of atopic dermatitis, allergic rhinitis and exercise-induced asthma.
By Naiem T. Issa, MD, PhD [1,2,3]
Subcutaneous Spesolimab Use in a Patient with Chronic Recurrent Generalized Pustular Psoriasis (GPP)
Case author Saakshi Khattri, MD, presents a case of a 61-year-old Asian female with a 30-year history of GPP who experienced a flare after months of remission following intravenous spesolimab, prompting a transition to subcutaneous maintenance therapy.
By Saakshi Khattri, MD
A Remarkable Result after a Lifetime of Disappointment in the Treatment of Severe, Recalcitrant Psoriasis
Case author Danna Calder, MMSc, PA-C presents a case of a 34-year-old male with severe, recalcitrant psoriasis achieving remarkable improvement after decades of treatment challenges.
By Danna Calder, MMSc, PA-C
Successful Management of Basal Cell Carcinoma in a Challenging Location with a Multimodal Approach
Case author Mark Lebwohl, MD, presents a case of a 86-year-old male with a progressively enlarging erythematous nodular mass with overlying telangiectases.
By Mark Lebwohl, MD
Tapinarof 1% Cream Effectively Clears Plaques of the Boney Prominences
Case author Brad Glick, DO, MPH, FAAD, presents the case of a 57-year-old female with worsening plaque psoriasis of the elbow who experienced limited responses to multiple therapies.
By Brad P. Glick, DO, MPH, FAAD
Rapid and sustained clearance of severe psoriasis with dual inhibition of IL-17A and IL-17F
Ron Vender, MD, FRCPC, presents the case of a 31-year-old male with an 8-year history of severe psoriasis who was frustrated with the lack of effective treatment options.
By Ron Vender, MD, FRCPC
A Case of Nonsegmental Vitiligo on the Face and Hands Treated With Combination Topical JAK Inhibitor and Phototherapy
Case authors Mavra Masood, MD, Jennifer Creasor, BSN, and Iltefat Hamzavi, MD, present a case of a 74-year-old female with persistent generalized vitiligo on the face and body.
By Mavra Masood, MD [1], Jennifer Creasor, BSN [1], Iltefat Hamzavi, MD [1]
Rapid Clearance of Recalcitrant Psoriasis With an IL-17 Inhibitor
Mark Lebwohl, MD, presents a case of a 48-year-old female with a 10-year history of psoriasis who was successfully treated with an IL-17 inhibitor after inadequate response to both phototherapy and a TNF blocker.
By Mark Lebwohl, MD
Successful Treatment of Nonsegmental Periorbital Vitiligo
Case author Stephen W. Lewellis, MD, PhD, FAAD, presents a case of a 38-year-old female with loss of pigmentation on her forehead, cheeks, and eyelids who did not respond to prior treatment with a topical corticosteroid or calcineurin inhibitor.
By Stephen W. Lewellis, MD, PhD, FAAD
Accurately Assessing Prognosis for High-Risk Squamous Cell Carcinoma
Case authors Danny Zakria, MD, MBA, Ryan Rivera-Oyola, MD, and Darrell Rigel, MD, MS, present a case of a 58-year-old male with a history of sun exposure and a skin lesion showing signs of malignancy.
By Danny Zakria, MD, MBA, Ryan Rivera-Oyola, MD, Darrell Rigel, MD, MS
A Life-Saving Treatment in a 60-year Old Patient With Rapid Eruption of Pustules
Case author Boni Elewski, MD and moderator Danny Zakria, MD, MBA, present a case of a 60-year old female who was airlifted in the middle-of-the-night with a rare dermatologic emergency.
By Boni Elewski, MD
Effective Primary Management of an Exacerbation of Atopic Dermatitis Using a Non-Steroidal Topical Therapy
Case authors Lisa C. Lopez-Sanglay, APRN, FNP-BC and James Q. Del Rosso, DO, FAAD, FAOCD present a case of a 15-year-old male with a flare of atopic dermatitis primarily affecting his hands and feet and a severely pruritic rash.
By James Q. Del Rosso, DO, FAAD, FAOCD and Lisa C. Lopez-Sanglay, APRN, FNP-BC
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