Atopic dermatitis (AD) is a chronic, relapsing inflammatory dermatosis characterized by epidermal barrier dysfunction, type 2–skewed immune activation, and intense pruritus with eczematous lesions. Disease expression varies by age and severity, with recurrent flares and a well-established association with atopic comorbidities including asthma, allergic rhinitis, and food allergy.
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Dr Jenny Murase presents a case of severe, dupilumab-refractory atopic dermatitis with idiopathic sudomotor failure successfully managed with lebrikizumab.
