Hyperhidrosis

WEDNESDAY, July 12, 2023 -- For patients aged 12 years and older with primary palmar hyperhidrosis (PPHH), 20 percent oxybutynin hydrochloride lotion (20 percent OL) is more effective than placebo for reducing palmar sweat volume, according to a study published in the July issue of the Journal of the American Academy of Dermatology.Tomoko Fujimoto, M.D., Ph.D., from the Ikebukuro Nishiguchi Fukurou Dermatology Clinic in Tokyo, and colleagues examined the efficacy of 20 percent OL for reducing palmar sweat volume in a randomized trial involving Japanese patients aged 12 years and older with PPHH. Participants received 20 percent OL or placebo (144 and 140, respectively) on both palms once daily for four weeks. Response was defined as a reduction of sweat volume of at least 50 percent from baseline.The researchers found that the responder rate for sweat volume was significantly higher in the 20 percent OL arm than the placebo arm at week four (52.8 versus 24.3 percent, respectively). There were no serious adverse events reported; none of the adverse events resulted in treatment discontinuation."When administered for four weeks, 20 percent OL is effective for the treatment of PPHH and has a favorable safety profile. Therefore, it may represent a promising treatment option for PPHH," the authors write.Several authors received fees from and others are employees of Hisamitsu Pharmaceutical Co., which funded the study and manufactures the 20 percent oxybutynin hydrochloride lotion.

20 percent oxybutynin hydrochloride lotion more effective than placebo for patients aged 12 years and older with primary palmar hyperhidrosis

How Well Does 20 Percent Oxybutynin Hydrochloride Lotion Cut Palmar Sweat Volume?

Several Old Spice and Secret aerosol spray antiperspirants and hygiene products have been voluntarily recalled in the United States due to the presence of benzene, Proctor &amp; Gamble says.




 Benzene exposure can occur by inhalation, orally, and through the skin. It can lead to cancers including leukemia and blood cancer of the bone marrow, as well as potentially life-threatening blood disorders.




 Proctor &amp; Gamble said that it has not received any reports of harm from the recalled products, which were distributed across the country. The recalled products have expiration dates through September 2023. The UPC codes, names, and descriptions are listed on the
 <a class="rm-stats-tracked" href="https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/pg-issues-voluntary-recall-specific-old-spice-and-secret-aerosol-spray-antiperspirants-and-old-spice" target="_blank">
 U.S. Food and Drug Administration website
 </a>
 .




 Consumers with the recalled products should stop using them and throw them away. They should contact their physician or health care provider if they have experienced any problems that may be related to using these products, Proctor &amp; Gamble advised.




 <a class="rm-stats-tracked" href="https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/pg-issues-voluntary-recall-specific-old-spice-and-secret-aerosol-spray-antiperspirants-and-old-spice" target="_blank">
 More Information
 </a>




 <a href="https://consumer.healthday.com/u/physiciansbriefingstaff">
 <img alt="HealthDay" src="https://assets.rbl.ms/23636171/origin.png" style="max-width: 150px;"/>
 </a>

Proctor &amp; Gamble said that it has not received any reports of harm from the recalled products

Hyperhidrosis Condition Center

Featured in Hyperhidrosis

Hyperhidrosis News & Research