JAK Inhibitors

In Episode 50 of Derms and Conditions, our host James Q. Del Rosso, DO, continues his conversation with Andrew Blauvelt, MD, MBA, a clinical trials investigator and former President and Owner of the Oregon Medical Research Center. Dr. Blauvelt has conducted almost 200 clinical trials on biologics and JAK inhibitors for the treatment of psoriasis and atopic dermatitis. While part one of this series focused on psoriasis, part two takes a deep dive into new therapies for atopic dermatitis.Dr. Blauvelt first discusses dupilumab and how this medication blazed the trail for the treatment of severe atopic dermatitis in patients with very limited options. Dr. Del Rosso clarifies the difference in mechanism of action between dupilumab and the newer drugs tralokinumab and lebrikizumab, and the two comment on how this impacts efficacy and safety. A common adverse effect seen with these drugs is eye related issues such as conjunctivitis and keratoconjunctivitis sicca, and they advise how to manage these conditions if they arise.Next, Dr. Del Rosso switches focus to the FDA-approved oral JAK inhibitors for atopic dermatitis, abrocitinib and upadacitinib. The biggest concern with JAK inhibitors has been their safety profile and black box warnings. However, Dr. Blauvelt discusses how these black box warnings came from a trial for tofacitinib to treat rheumatoid arthritis in a patient population featuring older patients with cardiac comorbidities that were taking prednisone and methotrexate concomitantly. This episode is full of clinical pearls for using the newest and most efficacious drugs for atopic dermatitis, so tune in to learn more!

In Episode 50 of Derms and Conditions, our host James Q. Del Rosso, DO, continues his conversation with Andrew Blauvelt, MD, MBA, a clinical trials investigator and former President and Owner of the Oregon Medical Research Center. Dr. Blauvelt has conducted almost 200 clinical trials on biologics and JAK inhibitors for the treatment of psoriasis and atopic dermatitis. While part one of this series focused on psoriasis, part two takes a deep dive into new therapies for atopic dermatitis.

 Andrew Blauvelt, MD, MBA

Derms and Conditions Podcast

From the Research Center to the Clinic: Biologics and Other Systemic Therapies Part 2

In Episode 33 of&nbsp;Derms and Conditions, host James Q. Del Rosso, DO sits down with April W. Armstrong, MD, MPH, Professor of Dermatology and Associate Dean at the University of Southern California and discuss&nbsp;the different members of the JAK family and how they enhance different intracellular signals.

In Episode 33 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with April W. Armstrong, MD, MPH, Professor of Dermatology and Associate Dean at the University of Southern California. The two discuss the Janus tyrosine kinase (JAK) pathway and how JAK inhibitors have become a useful tool in treating several chronic dermatologic conditions. Dr. Armstrong notes that different members of the JAK family pair in different ways and therefore enhance different intracellular signals. In fact, these pairings are why certain JAK inhibitors are used for certain disease states and subsequently lead to a variety of adverse effects. Dr. Armstrong emphasizes the importance of knowing which JAK molecule the drug acts upon and the associated side effects for clinical monitoring. She highlights that one member of the JAK family, TYK2, can have a more targeted effect based on where the molecule is inhibited and therefore lead to fewer adverse effects. She discusses an example of a common case encountered in practice and some of the relative and absolute contraindications to starting a JAK inhibitor. You won’t want to miss these important pearls that can help you navigate this complex but exciting area of therapeutics. JAMES DEL ROSSO, DO FINANCIAL DISCLOSURES: CONSULTANT/ADVISOR Abbvie, Aclaris, Almirall, Amgen, Arcutis, Bausch Health (Ortho Dermatology), BioFrontera, BioPharmX, Bristol-Myers-Squibb, Cassiopea, Dermata, Dermavant, Encore, EPI Health, Evommune, Ferndale, Galderma, Incyte, JEM Health, Leo Pharma, La Roche Posay, Lilly (Dermira), MC2, Novan, Pfizer, Regeneron, Sanofi-Genzyme, SolGel, Sonoma (IntraDerm), Sun Pharma, Trevi, UCB, Verrica, Vyne (Foamix; Menlo) SPEAKER BUREAU Aclaris, Almirall, Amgen, Arcutis, Bausch Health (Ortho Dermatology), EPI Health, Ferndale, Galderma, Genentech, JEM Health, Leo Pharma, La Roche Posay, Lilly (Dermira), Pfizer, Regeneron, Sanofi-Genzyme, Sun Pharma, UCB, Verrica, Vyne (Foamix; Menlo) RESEARCH INVESTIGATOR Aclaris, Almirall, Amgen, Anaptys Bio, Arcutis, Athenex, Bausch Health (Ortho Dermatology), BioPharmX, Biorasi, Botanix, Brickell, Cara Therapeutics, Cassiopea, Dermavant, EPI Health, Ferndale, Galderma, Incyte, Leo Pharma, Lilly (Dermira), Novan, Pfizer, Ralexar, Regeneron, SolGel, Sun Pharma, UCB, Verrica, Vyne (Foamix; Menlo). APRIL ARMSTRONG, MD, MPH FINANCIAL DISCLOSURES: Research investigator and/or scientific advisor to AbbVie, Almirall, Arcutis, ASLAN, BI, BMS, EPI, Incyte, Leo, UCB, Janssen, Lilly, Nimbus, Novartis, Ortho Dermatologics, Sun, Dermavant, Dermira, Sanofi, Regeneron, Pfizer, and Modmed.

JAK Inhibitors Condition Center

Featured in JAK Inhibitors

Do you compound any currently available JAK inhibitors into creams for topical use by your patients?

JAK Inhibitors Episodes to Explore

From the Research Center to the Clinic: Biologics and Other Systemic Therapies Part 2

Fundamentals of JAK Inhibitors and What Makes Them TYK