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Belimumab Promising in Combination Therapy for Refractory Lupus

Lower serum IgG anti-dsDNA antibody levels seen at 52 weeks with belimumab rather than placebo given after rituximab

By Physician’s Briefing Staff | October 26, 2021

For patients with systemic lupus erythematosus (SLE) refractory to conventional treatment, belimumab after rituximab significantly reduces serum immunoglobulin (Ig)G anti-double stranded DNA (dsDNA) levels and the risk for severe flare, according to a study published online Oct. 26 in the Annals of Internal Medicine.

Muhammad Shipa, M.B.B.S., from University College London, and colleagues conducted a phase 2 randomized trial involving 52 patients with SLE that was refractory to conventional treatment and whose physicians had recommended rituximab therapy. Patients were treated with rituximab and then randomly assigned four to eight weeks later to receive intravenous belimumab or placebo for 52 weeks.

The researchers found that IgG anti-dsDNA antibody levels were lower in belimumab-treated patients at 52 weeks compared with placebo-treated patients (geometric mean, 47 versus 103 IU/mL; 70 percent greater reduction from baseline). The risk for severe flare was reduced significantly with belimumab versus placebo (hazard ratio, 0.27), with three and 10 severe flares in the belimumab and placebo groups, respectively. There was no increase seen in the incidence of serious adverse events in the belimumab group.

"These findings support further exploration of belimumab after rituximab as the first combination biologic therapy for patients with SLE, at least in those whose disease is refractory to conventional therapy and/or requires high corticosteroid dosages," the authors write.

The study was funded primarily by Versus Arthritis; GlaxoSmithKline provided belimumab free of charge, as well as additional funding.

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