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Early Postoperative Microneedling May Improve Surgical Scars

Daxxify lasts longer than Botox, with about 80 percent of users seeing no or mild facial lines at four months after injection

By Physician’s Briefing Staff | September 09, 2022

People wanting to keep wrinkles at bay will soon have a new option now that the U.S. Food and Drug Administration has approved the first competitor for Botox in decades.

Daxxify, made by Revance Therapeutics Inc. in Nashville, Tennessee, is injected into the face along worry lines. It lasts longer than Botox, with about 80 percent of users seeing no or mild facial lines at four months after injection. For half of users, the treatment lasted six months, the company said in a statement .

"Users do not have to go once every three months," Balaji Prasad, M.D., who covers specialty pharmaceuticals as an analyst for Barclays Investment Bank, told The New York Times . "In a world where time is of the essence, having a product with a long duration factor is extremely useful."

The new drug now enters the $3 billion field of facial injection drugs. It is also a neuromuscular blocking agent and a botulinum toxin, like AbbVie's Botox. "It also opens up the door for what we can do with therapeutics," Revance CEO Mark Foley, told The Times . "If you think of migraines, cervical dystonia, overactive bladder, there's a huge medical opportunity as well."

The company has begun testing the drug on these other medical issues, Foley said. While the company had been trying to create a product that needed no needle, it instead discovered a way to use peptide technology to keep the product stable. Typically, animal protein or human serum is used.

Users of Daxxify in the Revance studies included some who experienced side effects. About 2 percent of people developed a drooping eyelid, while about 6 percent experienced headache, the company said. Toxin-based treatment can carry the potential for other side effects, such as general muscle weakness or breathing difficulties, the FDA cautioned. Daxxify study participants showed none of those symptoms.

The New York Times Article

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