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Infant skin infections associated with the development of childhood psoriasis

Among patients with plaque phenotype, high disease activity, and scalp lesions, 52 percent developed severe disease

By Physician's Briefing Staff | February 02, 2021

A study showing that dermatology in the first two years of life is associated with the development of childhood psoriasis was published in the Journal of the American Academy of Dermatology on December 12, 2020.

Yi-Ju Chen and colleagues from Taichung Veterans General Clinic (Taiwan) and colleagues from the 2000-2017 Taiwan National Health Insurance to investigate whether infancy infections and antibacterial drug exposure affect the development of childhood psoriasis. Conducted a nationwide in-cohort case-control study using the National Health Insurance Research Database of Taiwan. A control group with no history of psoriasis and psoriatic arthritis that matched 1,527 pediatric psoriasis patients by gender (54.1% male), age (9.9 ± 3.7 years), and 2000-2017 visits (181.8 times) 1 Data from 5,270 cases were analyzed.

As a result of multivariate analysis, atopic dermatitis [adjusted odds ratio (aOR) 2.07, 95% confidence interval (CI) 1.84 to 2.32, even after adjustment for factors such as personal attributes, delivery pattern, and complications of allergies and autoimmune diseases. , P <0.001], the mother (9.86, 6.89-14.10, P <0.001) and the first degree other than the mother (5.49, 3.91-7.70, P <0.001) in the family history are independent of childhood psoriasis. It became clear that it was related.

In addition, a conditional logistic regression analysis by the stepwise method was used to examine the association between antimicrobial exposure and infections and childhood psoriasis. Skin viral and bacterial infections within 2 years of age (aOR 1.35, 95% CI 1.13) There was a significant association between prevalence of ~ 1.62, P <0.001), and fungal infections (aOR 1.71, 95% CI 1.44-2.04, P <0.001) and childhood psoriasis. On the other hand, no correlation was found between antibiotic exposure within the first 2 years of life and childhood psoriasis.

"The results of this study suggest that skin and fungal infections in infancy are associated with the development of childhood psoriasis. Decreased bacterial flora diversity in infancy is associated with childhood psoriasis. It may be worth investigating further about the role it plays in the onset. " (HealthDay News February 2, 2021)

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