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Presymptomatic Transmission Seen With Monkeypox

Transmission detected up to a maximum of four days before onset of symptoms

By Physician’s Briefing Staff | November 03, 2022

Substantial monkeypox transmission occurs before symptoms appear or are detected, according to a study published online Nov. 2 in The BMJ.

Thomas Ward, from the U.K. Health Security Agency in London, and colleagues assessed transmission dynamics of the monkeypox outbreak in the United Kingdom. The analysis included contact tracing from 2,746 people with polymerase chain reaction-confirmed monkeypox virus between May 6 and Aug. 1, 2022.

The researchers estimated that the mean incubation period was 7.6 days using the interval censoring corrected model and 7.8 days using the interval censoring right truncation corrected model, while the estimated mean serial interval was 8.0 days and 9.5 days, respectively. While both models yielded a mean serial interval that was longer than the incubation period, short serial intervals were more common than short incubation periods, with the 25th centile and the median of the serial interval shorter than the incubation period. Ten of 13 linked patients had presymptomatic transmission documented. Four days was the maximum time that transmission was detected before symptoms manifested.

"An isolation period of 16 to 23 days would be required to detect 95 percent of people with a potential infection," the authors write.

Abstract/Full Text



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