WEDNESDAY, Feb. 21, 2024 -- The risk for subsequent cutaneous squamous cell carcinomas (cSCCs) increases with the number of prior cSCCs, while the time interval decreases with each subsequent cSCC, according to a study published in the March issue of the Journal of the American Academy of Dermatology.

Celeste J. Eggermont, M.D., from the Erasmus MC Cancer Institute in Rotterdam, Netherlands, and colleagues examined the cumulative incidence and timing of subsequent cSCCs using data from patients with a first cSCC in 2007 to 2008 from the Netherlands Cancer Registry linked to the Netherlands Pathology Registry for subsequent cSCCs and the Netherlands Organ Transplant Registry.

The researchers found that 4,325; 2,010; 1,138; 739; and 501 of the 12,345 patients had second to sixth cSCCs, with median time intervals of 1.4, 1.2, 0.9, 0.6, and 0.5 years, respectively, after the previous cSCC. At five years, the cumulative incidences of a subsequent cSCC increased from 28 to 67 percent for the second to sixth cSCC. The cumulative incidences increased from 74 to 92 percent for solid organ transplant recipients and from 41 to 64 percent for patients with hematologic malignancy.

"The majority of nonimmunocompromised patients with cSCC could benefit from more personalized follow-up schedules, taking into account the number of prior cSCCs and potentially reducing the total volume of follow-up visits," the authors write.

One author disclosed ties to Sanofi Genzyme.