Name: How does the pathophysiology in GPP differ from plaque type psoriasis?
Uploaded: 2023-06-27T00:00:00.000Z
Description: How does the pathophysiology in GPP differ from plaque type psoriasis?

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Dermbits

BI Spevigo July 2023

MD, PhD

How does the pathophysiology in GPP differ from plaque type psoriasis?  

Generalized Pustular Psoriasis (GPP)

<p class="MsoNormal">Now since GPP has, as its driver, IL-36, that's a little bit different than our classic plaque psoriasis. When IL-36 is overexpressed it then will bind to the IL-36 receptor, which is on the cell surface of all of our cells and as a consequence of that, they go in and activate this innate pathway which runs through NF Kappa. B. We see elevated levels of IL-36, so you think well, “So what?”, IL-36 drives neutrophil recruitment. Neutrophils come massively and infiltrate into the dermis and the epidermis resulting in pustules. And actually those pustules then go on to become confluent lakes of puss.&nbsp;<o:p></o:p></p>

How does the pathophysiology in GPP differ from plaque type psoriasis?

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