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Dermbits

MD, PhD

Gwyneth Paltrow is promoting Xeomin as a 'natural' Botox. In my 13 years, we mostly use Xeomin for people that are resistant to Botox or Dysport. Thoughts?

Aesthetics

So, number one, all type a toxins, every single one of them, work. It's exactly the same. And the reason that xiaomin is different is that it doesn't have in its native state, the complexing proteins that either Botox or dysport or jubot has. And those are obviously the approved toxins. However, it's been shown very clearly that you get disassociation of those proteins, literally in the syringe, if not immediately after it's injected. So those complex proteins don't seem to have a factor in this. From that perspective. The reason it's called natural, they're saying, is because it's the 150 kilojolton protein and not the complexing proteins. However, there is no evidence, or virtually no evidence that having those complexing proteins, number one, is increasing the immune resistance to toxin, either botox or dysport. And there's also no evidence that those people who are, quote, resistant, and I'll talk about that in a second, get better results from Xemin. It's all about the issue of molecular potency, and I've published on this. You can just look my name up. I published on Journal of Cosmetic Dermatology last year on this for the paper on the science of botulinum toxin, the postulate paper, so you can look that up. It's really about molecular potency. There are people who are genetically more resistant, and there probably is a mechanism where the receptor gets toned down as you inject more. It really does not seem to be an immune response for any of these toxins, per se.

Gwyneth Paltrow is promoting Xeomin as a natural Botox. In my 13 years we mostly use Xeomin for people that are resistant to Botox or Dysport. Thoughts?