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Dermbits

How concerned are you about the risk of thrombosis mentioned in the boxed warning for ruxolitinib cream?

Atopic Dermatitis

You. I am very minimally concerned about the risk of thrombosis associated with ruxalinidib cream. So we do know that there's some risk of thrombosis associated with oral jack inhibitors. We do know that a very small amount of topically applied ruxalinib, so about 6% will get absorbed systemically. So there is potential for systemic effects. But we also know that the side effects of the oral jack inhibitors seem to be very ghost related. And since we know that the systemic exposure to topical rexylin inhibits can be very low, I think that if there is any thrombosis risk associated with it is extremely, extremely minimal.