What are the traditional SCC prognostic paradigms?
Clinical Professor of Dermatology
Director, Melanoma Surveillance Clinic
Mount Sinai Icahn School of Medicine, New York, NY
Adjunct Professor, UT Southwestern Medical School
Consultant Dermatologist, Cooper Clinic, Dallas, TX
Typically, when we assess prognosis and squamous cell carcinoma, what's typically used is the AJCC criteria or the Boston Women and Brigham’s criteria and those basically are looking at clinical and histopathologic factors whether it’s a diameter of the lesion, whether it's the perineural invasion that's involved in a variety of other factors like that. But we're not really seeing the genomics. And that's the advantage of the 40-GEP test. It gives us additional information we can integrate into prognosis to better and more accurately assess.
In the video, Dr. Darrell Rigel discusses the traditional prognostic paradigms for squamous cell carcinoma (SCC). Currently, the two commonly used criteria are the AJCC (American Joint Committee on Cancer) criteria and the Boston Women and Brigham's criteria. These criteria rely on assessing clinical and histopathologic factors such as the diameter of the lesion and the presence of perineural invasion, among other factors. However, Dr. Rigel points out that these traditional paradigms do not take into account genomic information. This is where the 40-GEP test comes into play. The 40-GEP test provides additional genomic information, which can be integrated into the prognosis assessment to improve accuracy. By incorporating genomic data, clinicians can gain valuable insights into the underlying genetic characteristics of SCC, leading to a more comprehensive and refined prognosis for patients. This advancement in prognostic evaluation may ultimately aid in better treatment decision-making and patient outcomes.
- Traditional SCC prognostic paradigms: AJCC criteria, Boston Women, and Brigham’s criteria.
- Assessment of prognosis for squamous cell carcinoma based on clinical and histopathologic factors.
- Factors used in traditional criteria include diameter of the lesion and perineural invasion involvement.
- Traditional methods lack consideration of genomics in prognosis assessment.
- The 40-GEP test provides additional genomic information for better and more accurate prognosis integration.