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What is the 40-GEP test?

Featuring Darrell Rigel, MD, MS | Senior Clinical Advisor |

Clinical Professor of Dermatology 
New York University
Grossman School of Medicine
New York, NY 
Adjunct Professor
UT Southwestern Medical School 
Consultant Dermatologist, Cooper Clinic
Dallas, TX

| Published August 02, 2023


In the video, Dr. Darrell Rigel explains that the 40-GEP test is a new approach to assess prognosis with squamous cell carcinoma. The test utilizes gene expression profiles (genomics) to provide additional information beyond traditional clinical and histologic factors. By incorporating genomics, the 40-GEP test offers an extra dimension to better evaluate the prognosis of patients with squamous cell carcinoma, potentially leading to more accurate and personalized treatment decisions. 

Key Points 
  • The 40-GEP test is a test that utilizes gene expression profiles to assess prognosis in cases of squamous cell carcinoma. 
  • It represents a new approach in contrast to the traditional method of using clinical and histologic factors to determine prognosis. 
  • The test offers an advantage by introducing genomics as an additional dimension to improve the accuracy of prognosis assessment. 
  • The term "40-GEP" refers to the specific gene expression profile that is analyzed in the test. 
  • By incorporating genomic information, the 40-GEP test aims to provide a more comprehensive and precise evaluation of the prognosis for squamous cell carcinoma patients.

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