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Dermbits

BI Spevigo July 2023

MD, PhD

What is the pathophysiology of GPP?  

Generalized Pustular Psoriasis (GPP)

<p class="MsoNormal">The pathophysiology of GPP is very interesting. It does vary from plaque stage psoriasis. Now all of us are familiar now with the drivers of plaque stage psoriasis. We've learned IL-17, IL-23 can drive psoriasis. But it's a bit different in GPP. In GPP, what we see is extremely high levels of IL-36. IL-36 is an inflammatory cytokine which actually upregulates one of the innate immune response pathways, which then subsequently goes on to generate more IL-17 and IL-23. So, the target cytokine here is IL-36.<o:p></o:p></p>

What is the pathophysiology of GPP?

Related CME