What Changes When We Treat Psoriasis as Systemic Disease?

Updated:Apr 17, 2026

About this video

Psoriasis and psoriatic arthritis are understood as connected but often managed separately. Brad Glick, DO, MPH, walks through why that separation starts to break down in practice. 

Nearly a third of patients with psoriasis will develop joint involvement, many of whom remain undiagnosed. That reality demands screening become more intentional. Asking about morning stiffness, fatigue, joint swelling, or subtle changes that might otherwise be missed. 

With an oral TYK2 inhibitor that has demonstrated activity across both skin and joints, the conversation moves from what we treat to how we identify patients, when to intervene, and how we think about psoriasis as a systemic disease from the start.