The presentation on the comorbidities of psoriasis, led by Drs Bruce E. Strober, Joel M. Gelfand, and Karan Lal, highlighted the significant health risks associated with psoriasis. The presenters emphasized the strong connection between psoriasis and cardiovascular diseases, such as heart attack, stroke, and cardiovascular (CV) death, as well as metabolic disorders like obesity, diabetes, and hypertension, all of which are connected by the main factor of systemic inflammation. A meta-analysis showed that the severity and extent of psoriasis could be directly correlated to increased CV risk with a 1.18 and 1.41 increased risk of developing adverse outcomes in mild and severe psoriasis, respectively. It is recommended that dermatologists evaluate patients with psoriasis for CVD risk factors including elevated BMI, high cholesterol, high blood glucose, and high blood pressure levels, as well as screen and evaluate patients for psoriatic arthritis. The speakers broke down treatment options that not only manage psoriasis but also address its comorbidities, such as biologics and GLP-1 agonists, which may reduce cardiovascular risk.