James Song, MD, covers the strategies for combining systemics in the treatment of psoriasis and atopic dermatitis. He begins by explaining the benefit of combining systemic therapies and gives a friendly reminder to always be cautious of cutaneous T-cell lymphoma as the “great imitator”.  He then transitions to discussing the efficacy of and tips for combining systemic therapies. He first talks about combining methotrexate with biologics and then discusses the combination of biologics with cyclosporine, apremilast, and deucravacitinib. Dr. Song then talks about treating concomitant psoriasis and atopic dermatitis, a circumstance commonly seen in clinic. He finishes by covering a practical case of this situation effectively treated with the combination of ixekizumab and dupilumab.