Discuss the burden of itch on quality of life

Describe the pathophysiology of itch in atopic dermatitis

Analyze safety and efficacy data for current and emerging biologic therapies that target itch pathways in atopic dermatitis

Demonstrate strategies to individualize care to manage itch with biologic therapies in atopic dermatitis

Preventing Pruritus in Atopic Dermatitis: Are Biologics an Answer? Online CME Activity

Pruritus

WEDNESDAY, Feb. 7, 2024 -- Metformin does not appear to be associated with pruritus, according to a research letter published online Jan. 16 in SKIN.Lauren Sattele, from the Medical University of South Carolina in Charleston, and colleagues conducted a retrospective review of patients taking metformin, canagliflozin, insulin lispro, and insulin glargine between Jan. 1, 2012, and Nov. 14, 2022, using the U.S. Food and Drug Administration Adverse Event Reporting System to examine the association between metformin use and pruritus.The researchers found that the prevalence of pruritus was 0.7, 0.9, 0.4, and 0.6 percent for patients taking metformin, canagliflozin, insulin lispro, and insulin glargine, respectively. Compared with both insulin lispro and glargine, canagliflozin was significantly more likely to cause pruritus. Reports of pruritus among metformin users were not significantly different from those seen for users of the other three medications."Our results suggest that metformin is not significantly associated with pruritus and may be used for the treatment of dermatologic conditions with minimal concern for this adverse event," the authors write. "Canagliflozin, however, was significantly associated with pruritus."

Canagliflozin significantly more likely to cause pruritus than insulin lispro or insulin glargine

Metformin Use Not Significantly Linked to Pruritus

Episode 16 of Derms and Conditions has our host James Q. Del Rosso, DO speaking with Matthew Zirwas, MD about pruritus. Dr. Zirwas discusses the topical treatment of pruritis and offers a unique combination topical regimen that he often uses for his patients. He also presents some tips and tricks for treating Pruritus Ani.

Episode 16 of Derms and Conditions has our host James Q. Del Rosso, DO speaking with Matthew Zirwas, MD about pruritus. Dr. Zirwas discusses the topical treatment of pruritis and offers a unique combination topical regimen that he often uses for his patients. He also presents some tips and tricks for treating Pruritus Ani.&nbsp; Dr. Del Rosso and Dr. Zirwas also discuss a new non-steroidal, topical agent for pruritus. Dr. Zirwas discusses, in detail, the hypothesized mechanism of action for this novel agent and shares his success using it in his clinic. Finally, he briefly mentions some alternative oral agents for the pruritic patient. Financial Disclosures JAMES DEL ROSSO, DO FINANCIAL DISCLOSURES: CONSULTANT/ADVISOR Abbvie, Aclaris, Almirall, Amgen, Arcutis, Bausch Health (Ortho Dermatology), BioFrontera, BioPharmX, Bristol-Myers-Squibb, Cassiopea, Dermata, Dermavant, Encore, EPI Health, Evommune, Ferndale, Galderma, Incyte, JEM Health, Leo Pharma, La Roche Posay, Lilly (Dermira), MC2, Novan, Pfizer, Regeneron, Sanofi-Genzyme, SolGel, Sonoma (IntraDerm), Sun Pharma, Trevi, UCB, Verrica, Vyne (Foamix; Menlo) SPEAKER BUREAU Aclaris, Almirall, Amgen, Arcutis, Bausch Health (Ortho Dermatology), EPI Health, Ferndale, Galderma, Genentech, JEM Health, Leo Pharma, La Roche Posay, Lilly (Dermira), Pfizer, Regeneron, Sanofi-Genzyme, Sun Pharma, UCB, Verrica, Vyne (Foamix; Menlo) RESEARCH INVESTIGATOR Aclaris, Almirall, Amgen, Anaptys Bio, Arcutis, Athenex, Bausch Health (Ortho Dermatology), BioPharmX, Biorasi, Botanix, Brickell, Cara Therapeutics, Cassiopea, Dermavant, EPI Health, Ferndale, Galderma, Incyte, Leo Pharma, Lilly (Dermira), Novan, Pfizer, Ralexar, Regeneron, SolGel, Sun Pharma, UCB, Verrica, Vyne (Foamix; Menlo). MATTHEW ZIRWAS, MD FINANCIAL DISCLOSURES: Regeneron / Sanofi - Speaker, consultant, investigator Fit Bit - Consultant Genench / Novartis - Speaker L’Oreal - Consultant Menlo - Consultant AsepticMD - Part Owner Leo - Investigator, Consultant Janssen - Investigator Incyte - Investigator Foamix - Investigator UCB - Investigator Pfizer - Investigator, consultant Lilly - Investigator, consultant Asana - Investigator Avillion - Investigator Ortho Derm - Consultant Abbvie - Investigator Edessa Biotech - Investigator Galderma - Investigator Dermavant - Investigator Arcutis - Investigator, Consultant Sol-Gel - Consultant Bausch Health - Consultant EPI Health - Consultant, Investigator &nbsp;

Pruritus Condition Center

Featured in Pruritus

Pruritus Episodes to Explore

Clinical Pearls That You're "Itching" To Hear

Pruritus News & Research

Educational Courses You Might Like on Pruritus

Preventing Pruritus in Atopic Dermatitis: Are Biologics an Answer? Online CME Activity