Opzelura Drug Detail Page

Opzelura (ruxolitinib) cream 1.5%

Last updated: January 10, 2025

Disclaimer: This page is not intended to replace medical judgment.

Opzelura cream is a topically applied JAK inhibitor indicated for the treatment of atopic dermatitis and for nonsegmental vitiligo in patients over the age of 12. The package insert contains the same boxed warnings that have been applied to oral JAK inhibitors and include warnings about malignancy, major adverse cardiovascular events, thrombosis, serious infections, and death; but there is no evidence that these are increased with topical application of Opzelura cream. The package insert recommends against using in combination with biologics, other JAK inhibitors, or immunosuppressive drugs such as azathioprine and cyclosporine; but in clinical practice, Opzelura cream is often used in combination with other treatments for atopic dermatitis such as biologic therapies.

Latest research

Learn more about Opzelura

Atopic Dermatitis

1.5 Percent Ruxolitinib Cream Safe, Effective for Teens With Eczema

Ruxolitinib cream well tolerated, and disease control maintained over a year with as-needed use

By Lori Solomon (HealthDay News) | May 31, 2024

More Eczema Patients Achieve Itch-Free State With Ruxolitinib

Difference in itch numerical rating scale 0/1 was significant on day 2 and persisted through week 8

By Dermsquared Editorial Team | October 05, 2022

Does Ruxolitinib Exposure Increase NMSC Risk in Polycythemia Vera, Myelofibrosis?

Hazard ratio for nonmelanoma skin cancer was 2.69 for ruxolitinib-exposed patients; hazard ratio higher for SCC

By Dermsquared Editorial Team | October 27, 2021

What Is the Efficacy of Ruxolitinib Versus Vehicle in Atopic Dermatitis?

Significantly more patients receiving ruxolitinib achieved investigator's global assessment treatment success, significant reduction of pruritus

By Dermsquared Editorial Team | October 06, 2021

Vitiligo

Can ruxolitinib be used as a first-line treatment for vitiligo?

Video

Is there any recommended monitoring for patients on ruxolitinib for vitiligo?

Video

How does ruxolitinib compare to other treatment options for vitiligo?

Video

A Case of Nonsegmental Vitiligo on the Face and Hands Treated With Combination Topical JAK Inhibitor and Phototherapy

Case Study

Mavra Masood, MD [1], Jennifer Creasor, BSN [1], Iltefat Hamzavi, MD [1]

FAQs

Answers to frequently asked questions

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Generalized Idiopathic Pruritus Questionnaire

Check out our free Generalized Idiopathic Pruritus Questionnaire

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Topical Non-steroidal Therapies

Download our free Quick Reference Chart for Topical Non-steroidal and Fixed Combination Therapies

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JAK 1–3 & TYK2 Inhibitors in Dermatology

Download our free JAK/TYK2 Inhibitors for Dermatology Quick Reference Charts

Learn More

Vaccines and Systemic Therapies

Download our free Quick Reference Chart for Vaccines and Systemic Therapies Chart

Learn More

Biologic Medications for Psoriasis and Atopic Dermatitis

Download our free biologics for dermatology Quick Reference Charts

Learn More

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Opzelura (ruxolitinib) cream 1.5%

Latest research

Learn more about Opzelura

FAQs

Does Opzelura cream require any monitoring?

How quickly does Opzelura work?

Can Opzelura cream be used on facial or intertriginous sites?

Can application site reactions occur?