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Dermbits

MD, PhD, MSCI

What is the mechanism of action of topical roflumilast and how is it different than other PDE4 inhibitors?

Psoriasis

You. Topical reflumlase is an inhibitor of PDE four. That stands for phosphodiesterase four. This is an important enzyme that's involved in the pathogenesis of a lot of inflammatory diseases, just like psoriasis. Now, rofumalus is different than others you may have heard of, including crystaborol and a premalast, in part because it has much higher fold selectivity for that PDE four. Additionally, it's in a vehicle that's seems to deliver the drug really well, limiting any of those side effects you might be thinking about with other topical PDE four inhibitors, like stinging and burning. The clinical trials show that patients tolerated the cream very, very well and.

What is the mechanism of action of topical roflumilast and how is it different than other PDE4 inhibitors?

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