Chronic spontaneous urticaria (CSU) is a skin condition marked by the presence of red, swollen, itchy patches on the skin known as hives or wheals, which typically last less than 24 hours, and recur frequently, for a period exceeding 6 weeks.

This video provides a comprehensive look at the underlying mechanisms driving CSU, highlighting the pivotal role of mast cell and basophil degranulation and the central role of the high-affinity immunoglobulin (Ig)E receptor I (FcεRI) pathway and IgE and IgG antibodies in the autoimmune response.

Viewers will gain a deeper understanding of both type I autoimmunity and type 2b autoimmunity in CSU and the critical role of Bruton’s tyrosine kinase (BTK), a key mediator in the FcεRI signaling cascade that regulates mast cell degranulation and histamine release. Through this detailed exploration, viewers will learn about BTK's role in CSU pathogenesis.