Summary

In this video discussion, Dr Jim Del Rosso and Dr Leon Kircik talk about EpiCeram controlled release skin barrier emulsion. They highlight its formulation, which includes ceramides, fatty acids (conjugated linoleic acid [CLA] and palmitic acid), and cholesterol in a 3:1:1 ratio to simulate the intercellular lipid membrane of the skin barrier.  

They then discuss the indications for EpiCeram, which include treatment of dry skin conditions and managing symptoms associated with various dermatoses like atopic dermatitis, irritant contact dermatitis, and radiation dermatitis. 

Dr Kircik emphasizes the importance of EpiCeram's unique patented time-release system, which provides 24-hour barrier repair benefits with just one application a day. Dr Del Rosso and Dr Kircik explain the product's 2-sphere system and how the microsphere structure stabilizes the lipids from premature oxidation that can cause malodor in generic versions. 

Dr Del Rosso highlights the important role of CLA in the formulation of EpiCeram by referencing literature that has shown CLA used post-fractionated laser procedures has demonstrated significant improvement in inflammation, irritation, and swelling.

Dr Del Rosso and Dr Kircik then focus their conversation on radiation dermatitis and the ensuing barrier impairment. They emphasize the importance of treating radiation dermatitis early, since while the clinical signs of radiation dermatitis may take up to 3 weeks to appear, the barrier impairment can begin sooner. They conclude by highlighting the importance of maintaining the skin’s pH level to support epidermal barrier function.

Key Points

• EpiCeram formulation includes ceramides, fatty acids, and cholesterol in a 3:1:1 ratio to simulate the intercellular lipid membrane of the skin barrier
• EpiCeram has broad indications, including managing symptoms associated with various dermatoses like atopic dermatitis, irritant contact dermatitis, and radiation dermatitis
• EpiCeram uses a patented time-release system which provides 24-hour barrier repair benefits with one application a day
• While the product label recommends twice-daily application, data shows that once-daily application provides moisturization over 24 hours
• EpiCeram's 2-sphere system prevents malodor by stabilizing lipids from premature oxidation
• Early treatment is essential for radiation dermatitis, as barrier impairment can occur before clinical signs appear
• Maintaining the skin's pH level is crucial for epidermal barrier function
• EpiCeram should not be applied within 4 hours before radiation treatment, as recommended in the package insert