In this presentation, Gary Goldenberg, MD and Mark Nestor, MD, PhD, provided valuable insights into botulinum toxin (Botox) injections, collagen biostimulators, androgenetic alopecia (AGA) treatments, and innovative aesthetic devices for 2025. They began by discussing Botox injections, emphasizing that while all Type A toxins share the same mechanism of action, variations in results arise from differences in molecular potency, dosage, patient-specific factors (such as age, gender, and muscle mass), genetics, and injection technique. Using detailed diagrams, they highlighted optimal injection sites to achieve desired outcomes and noted how targeting the correct muscles not only influences facial aesthetics but may also impact mood through facial feedback.

The discussion then moved to collagen biostimulators, including poly-L-lactic acid (PLLA), calcium hydroxyapatite (CaHA), and cross-linked hyaluronic acid (HA). The presenters reviewed clinical studies, case results, potential mechanisms, and possible side effects of these biostimulators. For AGA, a variety of treatment options were explored, ranging from platelet-rich plasma and stem cells/exosomes (often paired with microneedling) to red light therapy, topical medications, vitamins, and low-dose oral minoxidil.

Lastly, the presentation introduced two cutting-edge aesthetic devices. RF microneedling was highlighted for its versatility in skin tightening and fat reduction, particularly in the infraorbital and submental regions. The Thulium 1928 nm laser was showcased as a promising tool for effectively treating pigmentary disorders, demonstrating excellent clinical results.