Immunology plays a significant role in dermatology, helping clinicians understand the mechanisms underlying many skin conditions and supporting the use of targeted cytokine therapies. In this lecture, Jason Hawkes, MD, MS, FAAD, shared a wealth of information to help dermatology providers learn and review the complex immunologic processes relevant to clinical practice. He offered clear explanations and illustrative diagrams of immune system pathways, while drawing clinical connections to conditions such as acne, atopic dermatitis, psoriasis, generalized pustular psoriasis, and chronic spontaneous urticaria. Dr Hawkes also demonstrated how many of the latest treatments fit into these pathways, making the content both accessible and directly applicable to patient care.