When Is Partial Improvement Enough to Stay the Course?

How long should clinicians give a treatment to demonstrate its value, and when does continued improvement become a plateau? In this follow-up, James Q. Del Rosso, DO, focuses on the trajectory of response in prurigo nodularis, looking at changes in itch intensity, lesion burden, and the development of new nodules over successive visits. He discusses the importance of allowing adequate time to assess biologic treatment while recognizing when progress has stalled and a change in strategy, whether through an additional therapy or a different approach, may be warranted.