Type 2 Inflammation Is a Network, Not a Single Pathway

IL-4 and IL-13 may sit at the center of the Type 2 conversation, but they are operating within a much larger immune network. Jason Hawkes, MD, follows that signaling outward, from T-cell differentiation and cytokine production to the innate and adaptive cells that join the response. Along the way, he considers why a shared inflammatory pathway can connect seemingly disparate conditions while still producing different symptoms, presentations, and patterns across a patient’s lifetime.