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Beyond the Pathway: How AhR Shapes Clinical Decision-Making

Featuring:

AAApril Armstrong, MD, MPHCo-Director

E(Elizabeth (Lisa) Swanson, MDFaculty

Updated:Aug 13, 2026

Atopic Dermatitis

About this video

As we continue to deepen understanding of the aryl hydrocarbon receptor (AhR), April Armstrong, MD, MPH, and Elizabeth (Lisa) Swanson, MD, explore why AhR has remained a relatively unfamiliar pathway for many clinicians despite years of clinical experience, and further, the relevance it has now.

Together, they discuss AhR agonism as a distinct therapeutic approach, its role in immune regulation, skin barrier restoration, and oxidative stress, and how those biologic effects translate into practical treatment decisions. Along the way, they compare AhR with other topical mechanisms, share how their own prescribing has evolved, and look ahead to what this emerging therapeutic class may teach us about inflammatory skin disease beyond today's indications.

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