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Dermbits

Is there data on using calcipotriene cream vs ointment in combination with 5-FU and does the order of application matter?

Actinic Keratoses

You. One of the ways to augment the activity of five Fu is the addition of calciupatrine, and a cream or a foam version of calcipatrine is readily available. These have been used pretty routinely now in healthcare systems such as Kaiser and hmos and there's basically a four day scheme looking at three months out. As far as an assessment, we're still looking for larger trials for anything pivotal as well as long term efficacy and recurrence data. I think it's an easy regimen to apply. There is a lot of irritation when you add the calcium petrine, either in ointment or cream foam to the already irritating five Fu. But enhancing its efficacy by increasing the activity of TSLP as an antigen as well as improving the epidermal turnover and changing differentiation are all really important consequences of using the two together. I think it allows for a good regimen as well as activity on service area. The real questions again come from long term recurrence frequency of cycles as well as the use in combinations. There was a nice trial. Dr. Angela Moore and her group did a foam study with calcipitrine foam mixed with five fu and showed some utility with cryotherapy, which I think is a really good way of applying it in a real world setting.