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Dermbits

Do you see WINLEVI replacing ACZONE?

Acne

You. We now have available a topical androgen receptor inhibitor, which is topical cliscodorone. It's FDA approved as a 1% cream applied twice a day in patients with acne that are at least twelve years of age. This is the first time we actually have an FDA approved androgen receptor inhibitor. It's available topically. So the data showed that it can be used in males and females with oral spironalactone, which is an androgen inhibitor that we use off label. It's utilized only in females, but it's important to recognize that topical clascodorone was studied in males and females and can be safely used in both. It's a unique mechanism of action. So a lot of people ask, is this going to replace topical dapsone or topical benzero peroxide or retinoids? It doesn't technically replace anything because it's working on a different pathophysiological pathway. So there's no immediate replacement of any other agent, whether it be topical or oral antibiotic for that matter, it doesn't replace any other therapies. It targets a specific pathophysiology, which is inhibition of androgen activity.