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Dermbits

What are the pros and cons of the different topical azelaic acid formulations?

Acne

You. So the prescription topical azalaic acid formulations that we have available are the 15% gel, the 15% foam and the 20% cream. Now, one thing I used to think was that, well, stronger or higher number must be better, but that may not necessarily be the case. The 20% is not necessarily better than the 15%. There are some in vitro studies that show that there's actually greater cutaneous penetration with the 15% gel versus the 20% cream. When we look about tolerability amongst the 15% products, the foam actually has reduced side effect profile or cutaneous adverse events compared to the 15% gel. There are no head to head studies. However, in the phase three studies of the foam, there were fewer incidence of cutaneous pain and paritis as compared to the 15% gel. So.