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Dermbits

DO, MPH

How quickly can patients see the onset of pustular clearance after a spesolimab infusion? 

Generalized Pustular Psoriasis (GPP)

You, the speed of this agent is actually pretty rapid and in the general sense, and even to some extent, what we saw in the clinical trials, that over 10% of the subjects in the first, just really 24 hours, had complete clearance of their pustules. And then, as we got between day two and up to about day ten, we had about 30% of the subjects in the clinical trials. And by the end of one week, 23 of over 50 subjects in the clinical trials, and then up to about over 65% of the subjects overall in that first week were actually able to achieve clearance of their posturals overall. So this drug works quite quickly. But I think that what we know, in the clinical sense, and what we've heard from our colleagues around the country, that we can see rapid responses with almost complete clearance in the first 24 hours, and a significant number of individuals in that 1st 48 hours.

How quickly can patients see the onset of pustular clearance after a spesolimab infusion?

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