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Are JAK inhibitors (specifically tofacitinib or ruxolitinib) an effective treatment option for alopecia areata?

Alopecia

So jack inhibitors specifically tofacitinib, and to some extent, even ruxalitinib for alopecia areata are a challenge. They work for alopecia areata. The problem is when you stop the therapy, it tends to relapse. There's been a couple of good papers out on ruxalitinib for patients who have failed tofacitinib therapy. And we've shown that in those papers that the authors actually published, that when you go up to the ten milligram dosing, potentially even ten milligrams twice a day, you get some nice treatment outcomes. Topacitinib, on the other hand, really, the data is quite mixed. And to be very frank, in my practice, it's not consistently been a slam dunk for every alopecia areata patient.