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Dermbits

Does roflumilast continue to be effective over a long period of time? 

Psoriasis

You in terms of efficacy. They did look at efficacy as a secondary endpoint in that long term study. And what they saw that was that 40% of patients had an IGA success at week 52. And what IG success means is that they go to an IG of zero, which is all clear, or one, which is almost clear, plus a two point improvement from their baseline IGA score, which is definitely a little harder because if a patient goes from an IGA of three to two, that's not a success, obviously. But if they go from, say, two to one, even though they meet iga one, which is almost clear, since this was not a two point improvement, they don't meet that IGA success score. So it's a pretty high bar, high standard. And even with that sort of high standard, high bar, 40% patients at meet 50 to met that metric. So there's definitely data on long term efficacy, which shows robust efficacy.