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Dermbits

BI Spevigo September 2023

DO, MPH

What is the recommended dosing regimen for spesolimab?

Generalized Pustular Psoriasis (GPP)

You? Well, it's 900 milligrams by intravenous infusion over 90 minutes, and that's one time. Now, I will comment that if there is not a desired response, and I can tell you from my experience, having used this agent and from what I know from my colleagues around the country that are using it, the response is typically rapid, and we may talk about that in a couple of minutes. But I will say that if the desired response is not achieved in the first week, a second dose of 900 milligrams intravenously can be utilized. If symptoms and signs persist, I do want to mention that the drug has to be diluted. It does come in a 450 milligram per 7.5 millimeter solution. So it's going to be utilized in two doses to create eight the 900 milligrams. And then again, it's a slow infusion, as I mentioned, and we typically not going to instill this into a second infusion site the second time. And what I mean by that is no other drug should be used parallel with this therapy, and that's very important.

What is the recommended dosing regimen for spesolimab?

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