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What are the advantages of JAK therapy vs. monoclonal antibody therapy for atopic dermatitis?

Atopic Dermatitis

You. So as a provider, as we're thinking about Jack inhibition, whether topical or systemic, versus monoclonal antibodies blocking Il four, IL 13, IL 31, the big thing to think about is that the jack inhibitors are much broader spectrum. So the monoclonal antibodies are very specific and blocking one antibody that may signal through the Jack pathway. But the Jack pathway, if we block it, we're actually the equivalent of hitting the person with multiple monoclonal antibodies. And so broader spectrum of action, which means there can work in things that are th one, like psoriasis, things that are th two, like atopic dermatitis, and things that are just inflammatory, like allergic contact dermatitis. So very broad spectrum activity compared to monoclonal antibodies. That being the main benefit. The other benefit, probably a significantly faster onset of action compared to monoclonal antibodies.