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Dermbits

What properties of roflumilast allow it to follow a once-daily dosing regimen?

Psoriasis

You. So flumalast is lipophilic, which means that it attracts lipids. Our skin has a lipid matrix. It isn't an aqueous base, which makes it non greasy and easy to use. And it does have a four day half life. So all these properties allow it to be dosed once a day. And historically, for psoriasis, when we've used topicals, we've used most of our topicals are twice a day. So to have a once a day formulation is something that makes it very easy for our patients to comply with. And I will say that compliance, when it comes to a topical regimen, really comes down to is it easy to use? Is it once a day? Which really is what ruptum lasa is all about.