Name: What are some of the biggest challenges in treating GPP?
Uploaded: 2023-09-01T00:00:00.000Z
Description: What are some of the biggest challenges in treating GPP?

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Dermbits

BI Spevigo September 2023

DO, MPH

What are some of the biggest challenges in treating GPP?

Generalized Pustular Psoriasis (GPP)

You. For me, up till now, until we've actually had a therapy to treat generalized postular psoriasis, is, in fact, indeed just that. We've never really had a drug in the toolbox specifically studied in a landmark, double blind, placebo controlled trial where subjects were treated with generalized postular psoriasis. Of course, now we have an agent in spizolama. But the challenges are that, whether it's early on or even when there's severe disease, this condition falls into the category of exfoliative erythroderma, where the skin is red and there may be a whole host of pustules. It's not so easy all the time to separate this from other conditions, whether it be other causes of exfoliative erythroderma, other pustular diseases like acute generalized ecthematis, postulosis, which usually there is a drug that initiates the event. So I think the challenges in general is sometimes the delay in diagnosis, potentially a misdiagnosis, and then, at least until previous, we had a hodgepodge of therapies, retinoids. We've been playing with certain biologic therapies, including tnf inhibitors, il 17 inhibitors, even il 23 inhibitors, and, of course, in the past, agents like methotrexate and cyclosporin. So now we have quite a drug specific therapeutic intervention by interleuking 36 inhibition by using an agent like spizolamol.

What are some of the biggest challenges in treating GPP?

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